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Angong Niuhuang Pills were invented by Wu Tang and documented in his work Wenbingtiaobian in 1798, and Tong Ren Tang began to produce Angong Niuhuang Pills thereafter. In 1870, Le Pingquan, the tenth generation of the Le family, firstly included the category of epidemic diseases in his amendment to the Tong Ren Tang Traditional Chinese Medicine Prescription and considered the Angong Niuhuang Pills as the preferred medicine for this category.
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Tong Ren Tang Angong Niuhuang Pills have a documented history of 149 years. Through over a hundred years of development, Tong Ren Tang integrated its owned medicine production techniques with the medicine production standards for the imperial family of Qing Dynasty, traditional Chinese medicine culture and Chinese culture, forming its owned traditional production techniques of Angong Nihuang Pills.